Effects of Justicia carnea Leave on Hematological Parameters in Albino Mice Carried Out in Mbingo Annex Hospital Laboratory in Bamenda, North West Region, Cameroon
Journal of Advances in Microbiology,
This study is design to ascertain the hematological status in albino mice treated with Justicia carnea leave, which could aid in the treatment of anemia. The hematological parameters investigated include Mean Cell Volume (MCV), Mean Cell Hemoglobin (MCH), Mean Cell Hemoglobin Concentration (MCHC), Platelets (PLTS), Hemoglobin (Hb), Red Blood Cells (RBCs), Pack Cell Volume (PCV) and White Blood Cells (WBCs). Nine (9) male albino mice of approximately the same weight 300 g were grouped into 3 groups that’s Negative Control (NC) Positive Control (PC) and Test Control (TC), each made up of 3 mice. Negative control mice were given normal feed moisten with water, Positive control received diluted iron folate with normal feed, finally Test control mice were administered powdered leaves of Justicia carnea with normal feed for 7 days, after which blood samples were collected using EDTA tubes by exsanguination and run for hematological parameters using auto-hematological analyzer. The results of various groups were found to be; as there was a significant increase in RBCs, Hb, & PCV (P=0.05), between the groups. No significant change was observed on the MCV, MCH, and MCHC. Lymphocytosis was observed in all groups with mark difference in granulocytosis. TC had granulocytosis, NC showed normal granulocyte scores and the PC show granulocytopenia with a statistical difference of P=0.0017. A significant difference was seen in platelets between the groups P=0.02. This study shows that J. carnea leaves possess anti-anemic potential, lending credence to the use of these plant leaves in folk medicine for the management of hemolytic anemia would be helpful. Further research on the various phytochemicals of the plant should be done and also its toxicological aspects.
- Hematological parameters
- albino mice
- and justicia caenea.
How to Cite
Janz TG, Johnson RC, Rubenstein SD. Anemia in the emergency department evaluation and treatment; 2013.
Merck Manual. Haematologic reference ranges. Mareck Veterinary Manual; 2012. Retrieved from http://www.merckmanuals.com/.
Ajagbonna CP, Onifade KI, Suleiman U. Hematological and Biochemical Changes in rats given extracts of Catotropics procera. Sokoto. J vet Sci. 1999;1:36-42.
Etim N, Joseph E, Glory E, Metiabasi U, Edem OM, AnthonyO. Hematological parameters and factors affecting their values, Akwa Ibom state university;2014.
Yakubu M, Musbau AA, Oladiji AJ. Hematological evaluation in male mice. Rats following chronic administration of aqueous extracts of Fadogia agrestis stem. Article from Pharmacognosy magazine. 2007;3(9):2007.
Shravan KD, Rajeshwar V, Anusha V, Tyothipriya J, Ravali T, Mounika M. Anti-anaemic activities of ethanolic extract of Punica granatum seeds on phenylhydrazin-induce anemic rats, India; 2016.
Iranloye BO. Effect of chronic garlic feeding on some hematological parameters. African Journal of biomedical Research. 2002;5:81-82.
Mansi K, Lahham J. Effects of pride of Artemisia sieberi Besser (A/ herba-alba) on heart rate and some hematological values in. normal and alloxan induced diabetic rats. Journal of Basic and Appliced Sciences. 2008;4:57-62.
Kuppast IJ, Vasudeva NP, Ravi MC, Biradar SS. Studies on the hematological effect of the extracts of Cordia dichotoma Forst. F. Fruits. Research Journal of Agriculture Science and Forestr. 2009;1: 195-204.
Okpuzor J, Ogbunugafor HA, Kareem GK. Hepatoprotective and hematologic effects of fractions of Globimetula braunii (Engle) in normal albino rats. EXCIL Journal. 2009;8:182-189.
Mishra N, Tandon VL. Hematological effects of aqueous extract of Bougainvillea spectabilis in Swiss Albino mice, India; 2011.
Owoyele BV, Oyelowo OT, Biliamina SA, Alaran ON, Alimi SA, Salia RS. Haematological and Biochemical studies on Parquetina nigrescene root extract in albino rats, Nigeria; 2011.
Mishra N, Tandon VL. Hematological effects of aqueous extract of Ornamental plants in Swiss Albino mice, India; 2011.
Obel H Jorum. Hematological effects of Dichloromethane-methanolic leaf extracts of Carissa edulis in Normal rats model, Kenya; 2016.
Adedapo AA, Abatan MO, Olorunsogo OO. Effect of some plants of the spurge family on haematological and biochemical parameters in rats. Veterinarski Arhiv. 2007;77:2938.
Bashir L, Shittu OK, Busari MB, Sani S, Aisha MI. Safety evaluation of giant African land snails Hemolymph on Hematological and Biochemical paramaters of albino rats. J Adv Med. Pharmaceut. Sci. 2015;3:122-130.
Olusegun RJ, Josiah O, Lugman AO, Ayokunle O, Sikiru AB. Effects of aqueous extracts of Ocimum gratissimum on Hematological parameters of wistar rats, Nigeria; 2008.
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