Impact of Different Chemically Synthesized Silver Nanoparticles on Nosocomial Infection
Mohamed Abdel-Raouf
Gastroenterology Surgical Center (GEC), Mansoura University, Mansoura, Egypt.
Hisham M. Aldeweik *
Gastroenterology Surgical Center (GEC), Mansoura University, Mansoura, Egypt.
Mohamed S. Albannan
Department of Research and Development, Biotechnology Research Center, Egypt.
Mohamed M. Zaki
Faculty of Science, Port Said University, Port Said, Egypt.
Ahmed E. Abdelkader
Faculty of Science, Port Said University, Port Said, Egypt.
Dalia Moemen
Faculty of Medicine, Mansoura University, Mansoura, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Aim: Nosocomial infection (NI), or so-called hospital-acquired infection, is one of the most important problems facing us and the world at this time. This study aims to investigate the effect of minimum inhibition concentration of Ag-NPs on isolated bacteria from nosocomial infections.
Place and Duration of Study: Gastroenterology Surgical Center, Mansoura University, Mansoura, Egypt, between July 2017 and July 2018.
Methodology: A total of 368 different samples of 100 patients were taken which staying for 3 days or more in Gastroenterology Surgical Center, Mansoura University, Egypt. Three different types of Ag-NPs synthesized by three different chemical methods were used.
Results: The results showed that the highest rate of infection of NI was found in K. Pneumoniae with an estimated percentage of 40%. The size of spherical Citrated-Ag-NPs was found in the range of 15-57 nm. On the contrary, the size of spherical Polyvinyl-Pyrrolidone (PVP) and PVP Glucose Ag-NPs were found to be smaller with size ranging from 7.8-23 and 7.58-25 nm, respectively.
Conclusion: Our findings showed that PVP Glucose Ag-NPs had the highest impact on all types of isolated bacteria associated with nosocomial infections.
Keywords: Nosocomial infections, Ag-NPs, K. pneumoniae, MRSA, E. coli.