Hemato- Biochemical Profile of Malaria Patients in Sub Saharan Africa: A Case of the Urban Health Center of Franceville, Gabon
Thiéry NDONG MBA
*
Laboratory of Molecular and Cellular Biology, University of Sciences and Techniques of Masuku, BP 943, Franceville, Gabon and Research Laboratory in Biochemistry, University of Sciences and Techniques of Masuku, BP 943, Franceville, Gabon.
Elvis Jolinom MBOT
Research Laboratory in Biochemistry, University of Sciences and Techniques of Masuku, BP 943, Franceville, Gabon.
Gabriel EDZODZOMO
Urban Health Center in Franceville, BP 942, Franceville, Gabon.
Arnaud Brice PAMBO-PAMBO
Laboratory of Molecular and Cellular Biology, University of Sciences and Techniques of Masuku, BP 943, Franceville, Gabon.
Cédric SIMA OBIANG
Research Laboratory in Biochemistry, University of Sciences and Techniques of Masuku, BP 943, Franceville, Gabon.
Hilaire KENGUELE MOUNDOUNGA
Laboratory of Molecular and Cellular Biology, University of Sciences and Techniques of Masuku, BP 943, Franceville, Gabon.
Louis Clément OBAME ENGONGA
Research Laboratory in Biochemistry, University of Sciences and Techniques of Masuku, BP 943, Franceville, Gabon.
*Author to whom correspondence should be addressed.
Abstract
Hemato-biochemical analysis is essential for optimal management, reducing the mortality and sequelae of malaria, particularly in endemic areas such as Gabon. This cross-sectional study examined hematological and biochemical changes associated with malaria in 154 patients at the Franceville Urban Health Center (July-September 2024). A high malaria prevalence of 66.88% (95% CI: 0.6-0.74), a severe reduction in erythrocytes (OR=16.59, 95% CI[6.82-43.94], p<0.001), elevated leukocytes (OR=5.6, 95% CI[2.57-2.7], p<0.001), marked thrombocytopenia (OR=15.59, 95% CI[5.86-49.3], p<0. 001), a significant increase in ALT (OR=6.67, 95% CI [3.85-20.47], p<0.001), an increase in AST in 42.21% of patients (OR=0.37, 95% CI [0.14-0.88], p<0.001), and finally, an increase in CRP levels (OR=0.6, 95% CI [0.28-1.26], p<0.001), were found as results.
This study demonstrates the profound effects of malaria on the hematopoietic and hepatic systems, underlining the need for comprehensive monitoring of these parameters in clinical management.
Keywords: Malaria, hematology, biochemistry, profile transaminases, c-reactive protein, Gabon